"Question: what do you do when everything in your venture seems to fail or fall flat?
Answer: you keep doing the doable until a stakeholder self-selects and invests some real skin in the game.
If you think effectual action cannot win you a Nobel prize, think again. Or, better still, ask Katalin Karikó.

First Love
Karikó began work on "Messenger RNA" in her early 20s in a doctoral program in Hungary. At the time, nobody knew whether this research would be of any value, so much so that the project ran out of funding. As Karikó explains: "The Nobel Prize winner who got it for RNA acknowledges that he never thought that RNA will be ever be a medicine" (Karikó, 2021)."